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Target
Endothelin-converting enzyme 1
Ligand
BDBM50287877
Substrate
n/a
Meas. Tech.
ChEBML_64372
IC50
25±n/a nM
Citation
 Deprez, P; Guillaume, J; Dumas, J; Vevert, JP Thiol inhibitors of endothelin-converting enzyme Bioorg Med Chem Lett 6:2317-2322 (1996)    Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE)
Type:
Protein
Mol. Mass.:
86126.89
Organism:
Rattus norvegicus (Rat)
Description:
P42893
Residue:
762
Sequence:
MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
  
Inhibitor
Name:
BDBM50287877
Synonyms:
(S)-2-[3-(4-Bromo-phenyl)-2-mercaptomethyl-propionylamino]-3-(1H-indol-3-yl)-propionic acid | CHEMBL77836
Type:
Small organic molecule
Emp. Form.:
C21H21BrN2O3S
Mol. Mass.:
461.372
SMILES:
OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(CS)Cc1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: