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Target
GTPase HRas
Ligand
BDBM50287944
Substrate
n/a
Meas. Tech.
ChEBML_143166
IC50
10000±n/a nM
Citation
 Wolin, R; Wang, D; Kelly, J; Afonso, A; James, L; Kirschmeier, P; McPhail, AT Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras Bioorg Med Chem Lett 6:195-200 (1996)    Article 
Target
Name:
GTPase HRas
Synonyms:
GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:
Other Protein Type
Mol. Mass.:
21293.37
Organism:
Homo sapiens (Human)
Description:
P01112
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
  
Inhibitor
Name:
BDBM50287944
Synonyms:
(E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yloxy]-1-phenyl-propenone | CHEMBL304637
Type:
Small organic molecule
Emp. Form.:
C25H22ClN3O6
Mol. Mass.:
495.912
SMILES:
COc1ccc2nc3n(nc(C)c3c(Cl)c2c1)[C@@H]1O[C@H](O\C=C\C(=O)c2ccccc2)[C@@H](O)[C@H]1O
Structure:
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