Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM50288285
Substrate
n/a
Meas. Tech.
ChEBML_3407
Kd
0.150000±n/a nM
Citation
 Paulis, Td; Trivedi, BL; Zhang, ZJ; Schmidt, DE; Ebert, MH; Hewlett, WA (S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor Bioorg Med Chem Lett 6:2657-2662 (1996)    Article 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
Zacopride site-R | 5-hydroxytryptamine receptor 3A | 5-HT3 | 5HT3A_RAT | Htr3a | 5ht3 | Htr3 | Serotonin (5-HT) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
Rat
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50288285
Synonyms:
N-(S)-1-Aza-bicyclo[2.2.2]oct-3-yl-5-chloro-3-iodo-2-methoxy-benzamide | CHEMBL90314
Type:
Small organic molecule
Emp. Form.:
C15 H18 Cl I N2 O2
Mol. Mass.:
420.67309
SMILES:
COc1c(I)cc(Cl)cc1C(=O)N[C@@H]1CN2CCC1CC2 |wU:13.13,(16.29,-14.6,;16.29,-13.05,;14.96,-12.28,;13.61,-13.05,;13.61,-14.67,;12.28,-12.28,;12.28,-10.73,;10.87,-9.92,;13.61,-9.96,;14.96,-10.73,;16.29,-9.96,;16.29,-8.41,;17.64,-10.73,;18.97,-9.96,;20.29,-10.73,;21.62,-9.97,;21.63,-8.44,;20.3,-7.66,;18.95,-8.42,;19.71,-9.75,;21.04,-8.99,)|
Structure:
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