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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50288289
Substrate
n/a
Meas. Tech.
ChEBML_159735
IC50
1.2±n/a nM
Citation
 Friesen, RW; Dubé, D; Fortin, R; Frenette, R; Prescott, S; Cromlish, W; Greig, GM; Kargman, S; Wong, E; Chan, CC; Gordon, R; Xu, LJ; Riendeau, D Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors Bioorg Med Chem Lett 6:2677-2682 (1996)    Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Type:
Enzyme
Mol. Mass.:
69003.89
Organism:
Homo sapiens (Human)
Description:
Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI).
Residue:
604
Sequence:
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM50288289
Synonyms:
1-Methanesulfonyl-4-(3-methylene-2-phenyl-cyclobut-1-enyl)-benzene | CHEMBL91118
Type:
Small organic molecule
Emp. Form.:
C18H16O2S
Mol. Mass.:
296.383
SMILES:
CS(=O)(=O)c1ccc(cc1)C1=C(C(=C)C1)c1ccccc1 |t:11|
Structure:
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