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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50072190
Substrate
n/a
Meas. Tech.
ChEBML_202904
Ki
920±n/a nM
Citation
 Abell, AD; Brandt, M; Levy, MA; Holt, DA A comparison of steroidal and non-steroidal inhibitors of human steroid 5α-reductase: New tricyclic aryl acid inhibitors of the type-1 isozyme Bioorg Med Chem Lett 6:481-484 (1996)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50072190
Synonyms:
(R)-8-Chloro-4,10b-dimethyl-1,5,6,10b-tetrahydro-2H-phenanthridin-3-one | CHEMBL97266
Type:
Small organic molecule
Emp. Form.:
C15H16ClNO
Mol. Mass.:
261.747
SMILES:
CC1C(=O)CC[C@@]2(C)C1=NCc1cc(Cl)ccc21 |t:9|
Structure:
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