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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50289041
Substrate
n/a
Meas. Tech.
ChEBML_28171
IC50
6400±n/a nM
Citation
 Sliskovic, DR; Picard, JA; Roark, WH; Essenburg, AD; Krause, BR; Minton, LL; Reindel, JF; Stanfield, RL Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. The synthesis and biological activity of a series of malonester amides Bioorg Med Chem Lett 6:713-718 (1996)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50289041
Synonyms:
CHEMBL349908 | N-(2,4-Difluoro-phenyl)-malonamic acid 2,6-diisopropyl-phenyl ester
Type:
Small organic molecule
Emp. Form.:
C21H23F2NO3
Mol. Mass.:
375.409
SMILES:
CC(C)c1cccc(C(C)C)c1OC(=O)CC(=O)Nc1ccc(F)cc1F
Structure:
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