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Target
Cholesteryl ester transfer protein
Ligand
BDBM50289152
Substrate
n/a
Meas. Tech.
ChEBML_48928
IC50
5000±n/a nM
Citation
 Xia, Y; Mirzai, B; Chackalamannil, S; Czarniecki, M; Wang, S; Clemmons, A; Ahn, HS; Boykow, GC Substituted 1,3,5-triazines as cholesteryl ester transfer protein inhibitors Bioorg Med Chem Lett 6:919-922 (1996)    Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50289152
Synonyms:
2-{4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-6-piperazin-1-yl-[1,3,5]triazin-2-yl}-1,2,3,4-tetrahydro-isoquinoline | CHEMBL366848
Type:
Small organic molecule
Emp. Form.:
C26H31ClN8
Mol. Mass.:
491.031
SMILES:
Clc1ccc(cc1)N1CCN(CC1)c1nc(nc(n1)N1CCc2ccccc2C1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: