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Target
Cholesteryl ester transfer protein
Ligand
BDBM50289156
Substrate
n/a
Meas. Tech.
ChEBML_48928
IC50
12000±n/a nM
Citation
 Xia, Y; Mirzai, B; Chackalamannil, S; Czarniecki, M; Wang, S; Clemmons, A; Ahn, HS; Boykow, GC Substituted 1,3,5-triazines as cholesteryl ester transfer protein inhibitors Bioorg Med Chem Lett 6:919-922 (1996)    Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50289156
Synonyms:
2-[4-(4-Chloro-phenyl)-piperazin-1-yl]-4-phenylethynyl-6-piperazin-1-yl-[1,3,5]triazine | CHEMBL171298
Type:
Small organic molecule
Emp. Form.:
C25H26ClN7
Mol. Mass.:
459.974
SMILES:
Clc1ccc(cc1)N1CCN(CC1)c1nc(nc(n1)N1CCNCC1)C#Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: