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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50289761
Substrate
n/a
Meas. Tech.
ChEBML_37417
IC50
7000±n/a nM
Citation
 Ogawa, S; Mito, T; Taiji, E; Jimbo, M; Yamagishi, K; Inokuchi, Ji Synthesis and biological evaluation of four stereoisomers of PDMP-analogue, N-(2-decylamino-3-hydroxy-3-phenylprop-1-yl)-β-valienamine, and related compounds Bioorg Med Chem Lett 7:1915-1920 (1997)    Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50289761
Synonyms:
CHEMBL58383 | Decanoic acid {(1R,2S)-2-hydroxy-2-phenyl-1-[(2,3,4-trihydroxy-5-hydroxymethyl-cyclohexylamino)-methyl]-ethyl}-amide
Type:
Small organic molecule
Emp. Form.:
C26H44N2O6
Mol. Mass.:
480.6374
SMILES:
CCCCCCCCCC(=O)N[C@H](CNC1CC(CO)C(O)C(O)C1O)[C@@H](O)c1ccccc1
Structure:
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