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Target
Isoleucine--tRNA ligase, cytoplasmic
Ligand
BDBM50290687
Substrate
n/a
Meas. Tech.
ChEBML_88805
IC50
300±n/a nM
Citation
 Carcanague, DR Novel derivatives of pseudomonic acid Bioorg Med Chem Lett 7:2805-2808 (1997)    Article 
Target
Name:
Isoleucine--tRNA ligase, cytoplasmic
Synonyms:
IARS | IARS1 | Isoleucyl-tRNA synthetase | SYIC_HUMAN
Type:
PROTEIN
Mol. Mass.:
144489.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_88804
Residue:
1262
Sequence:
MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTADF
  
Inhibitor
Name:
BDBM50290687
Synonyms:
9-{(E)-4-[(2S,3R,4R,5S)-5-(Butane-1-sulfonylamino)-3,4-dihydroxy-tetrahydro-pyran-2-yl]-but-2-enoyloxy}-nonanoic acid methyl ester | CHEMBL95037
Type:
Small organic molecule
Emp. Form.:
C23H41NO9S
Mol. Mass.:
507.638
SMILES:
CCCCS(=O)(=O)N[C@H]1CO[C@@H](C\C=C\C(=O)OCCCCCCCCC(=O)OC)[C@H](O)[C@@H]1O
Structure:
Search PDB for entries with ligand similarity: