Reaction Details
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Report a problem with these dataTarget
5-hydroxytryptamine receptor 1D
Ligand
BDBM50290916
Substrate
n/a
Meas. Tech.
ChEBML_1732
Ki
3.6±n/a nM
Citation
Jorand-Lebrun, C; Pauwels, PJ; Palmier, C; Chopin, P; Moret, C; Marien, M; Halazy, S Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists Bioorg Med Chem Lett 7:3183-3188 (1997) Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
Inhibitor
Name:
BDBM50290916
Synonyms:
4-o-Tolyl-piperazine-1-carboxylic acid 4-chloro-3-(4-methyl-piperazin-1-yl)-phenyl ester; compound with (E)-but-2-enedioic acid | CHEMBL107772
Type:
Small organic molecule
Emp. Form.:
C23H29ClN4O2
Mol. Mass.:
428.955
SMILES:
CN1CCN(CC1)c1cc(OC(=O)N2CCN(CC2)c2ccccc2C)ccc1Cl
Structure:
