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Target
Kappa-type opioid receptor
Ligand
BDBM50290977
Substrate
n/a
Meas. Tech.
ChEBML_145675
EC50
>10000±n/a nM
Citation
 Sabin, V; Horwell, DC; McKnight, AT; Broqua, P trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists Bioorg Med Chem Lett 7:291-296 (1997)    Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50290977
Synonyms:
2,2-Diphenyl-cyclopropanecarboxylic acid methyl-((1S,2S)-2-pyrrolidin-1-yl-cyclohexyl)-amide | CHEMBL319768
Type:
Small organic molecule
Emp. Form.:
C27H34N2O
Mol. Mass.:
402.5717
SMILES:
CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)C1CC1(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: