Reaction Details Report a problem with these data
Target
Endothelin receptor type B
Ligand
BDBM50290979
Substrate
n/a
Meas. Tech.
ChEBML_63709
IC50
>2500±n/a nM
Citation
Patt, WC; Reisdorph, BR; Repine, JT; Doherty, AM; Haleen, SJ; Walker, DM; Welch, KM; Flynn, MA; Hallak, H; Reyner, EL; Stewart, BH γ-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs Bioorg Med Chem Lett 7:297-302 (1997) Article
More Info.:
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
Inhibitor
Name:
BDBM50290979
Synonyms:
((S)-1-Naphthalen-1-yl-ethyl)-carbamic acid 4-benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-5-oxo-3-(3,4,5-trimethoxy-benzyl)-2,5-dihydro-furan-2-yl ester | CHEMBL322920
Type:
Small organic molecule
Emp. Form.:
C41H37NO10
Mol. Mass.:
703.7332
SMILES:
COc1ccc(cc1)C1(OC(=O)N[C@@H](C)c2cccc3ccccc23)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OC)c1)c1ccc2OCOc2c1 |c:31|