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Target
Endothelin receptor type B
Ligand
BDBM50057176
Substrate
n/a
Meas. Tech.
ChEBML_63709
IC50
>25000±n/a nM
Citation
 Patt, WC; Reisdorph, BR; Repine, JT; Doherty, AM; Haleen, SJ; Walker, DM; Welch, KM; Flynn, MA; Hallak, H; Reyner, EL; Stewart, BH γ-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs Bioorg Med Chem Lett 7:297-302 (1997)    Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50057176
Synonyms:
3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-methoxy-5-(4-methoxy-phenyl)-5H-furan-2-one | CHEMBL276173
Type:
Small organic molecule
Emp. Form.:
C26H22O6
Mol. Mass.:
430.4493
SMILES:
COc1ccc(cc1)C1(OC)OC(=O)C(=C1Cc1ccccc1)c1ccc2OCOc2c1 |c:15|
Structure:
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