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Target
Squalene synthase
Ligand
BDBM50291590
Substrate
n/a
Meas. Tech.
ChEBML_69353
IC50
2300±n/a nM
Citation
 Kwon, BM; Lee, SH; Kim, KS; Lee, IR; Lee, UC; Hong, SH; Bok, SH Rhombenone: farnesyl protein transferase inhibitor from the leaves of Hedera rhombea Bean Bioorg Med Chem Lett 7:971-974 (1997)    Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50291590
Synonyms:
6-Hydroxy-17-(1-hydroxy-1-methyl-5-oxo-hex-3-enyl)-4,4,8,10,14-pentamethyl-hexadecahydro-cyclopenta[a]phenanthren-3-one | CHEMBL366715
Type:
Small organic molecule
Emp. Form.:
C29H46O4
Mol. Mass.:
458.6731
SMILES:
CC(=O)CC=C[C@](C)(O)[C@H]1CC[C@]2(C)C1CCC1[C@@]3(C)CCC(=O)C(C)(C)[C@@H]3[C@@H](O)C[C@@]21C |w:4.3|
Structure:
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