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Target
Histamine H3 receptor
Ligand
BDBM50070217
Substrate
n/a
Meas. Tech.
ChEMBL_481041 (CHEMBL996660)
IC50
500±n/a nM
Citation
 Mierzwa, R; King, A; Conover, MA; Tozzi, S; Puar, MS; Patel, M; Coval, SJ; Pomponi, SA Verongamine, a Novel Bromotyrosine-Derived Histamine H3-Antagonist from the Marine Sponge Verongula gigantea J Nat Prod 57:175-177 (1994) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50070217
Synonyms:
3-(3-Bromo-4-methoxy-phenyl)-2-[(E)-hydroxyimino]-N-[2-(1H-imidazol-4-yl)-ethyl]-propionamide | CHEMBL15075 | VERONGAMINE
Type:
Small organic molecule
Emp. Form.:
C15H17BrN4O3
Mol. Mass.:
381.224
SMILES:
COc1ccc(CC(N=O)C(=O)NCCc2cnc[nH]2)cc1Br
Structure:
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