Reaction Details Report a problem with these data
Target
Sphingosine kinase 1
Ligand
BDBM50293709
Substrate
n/a
Meas. Tech.
ChEMBL_571685 (CHEMBL1032133)
IC50
2190±n/a nM
Citation
 Qu, W; Ploessl, K; Truong, H; Kung, MP; Kung, HF Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. Bioorg Med Chem Lett 19:3382-5 (2009) [PubMed]  Article 
Target
Name:
Sphingosine kinase 1
Synonyms:
SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1)
Type:
Enzyme
Mol. Mass.:
42521.16
Organism:
Homo sapiens (Human)
Description:
Q9NYA1
Residue:
384
Sequence:
MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLLRLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFWMVSGCVEPPPSWKPQQMPPPEEPL
  
Inhibitor
Name:
BDBM50293709
Synonyms:
(2S,3R,E)-2-Amino-15-(4-iodophenyl)pentadec-4-ene-1,3-diol | CHEMBL561296
Type:
Small organic molecule
Emp. Form.:
C21H34INO2
Mol. Mass.:
459.4046
SMILES:
N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCc1ccc(I)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: