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Target
Kinesin-like protein KIF3B
Ligand
BDBM50293771
Substrate
n/a
Meas. Tech.
ChEMBL_571922 (CHEMBL1035571)
IC50
>50000±n/a nM
Citation
 Lahue, BR; Ma, Y; Shipps, GW; Seghezzi, W; Herbst, R Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors. Bioorg Med Chem Lett 19:3405-9 (2009) [PubMed]  Article 
Target
Name:
Kinesin-like protein KIF3B
Synonyms:
KIAA0359 | KIF3B | KIF3B_HUMAN
Type:
PROTEIN
Mol. Mass.:
85132.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_571922
Residue:
747
Sequence:
MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIPNSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLSSFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIMNRAFFDEEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENIVLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSKARPKSGRKSGSSSSSSGTPASQLYPQSRGLVPK
  
Inhibitor
Name:
BDBM50293771
Synonyms:
2-(3-aminopyrrolidin-1-yl)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | CHEMBL564345
Type:
Small organic molecule
Emp. Form.:
C20H19F3N4O2
Mol. Mass.:
404.3857
SMILES:
NC1CCN(C1)c1nc2cc(ccc2n1Cc1ccccc1C(F)(F)F)C(O)=O
Structure:
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