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Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50293836
Substrate
n/a
Meas. Tech.
ChEMBL_572369 (CHEMBL1035270)
pH
8.5±n/a
Ki
22700±n/a nM
Comments
extracted
Citation
 Keough, DT; Hocková, D; Holý, A; Naesens, LM; Skinner-Adams, TS; Jersey, J; Guddat, LW Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J Med Chem 52:4391-9 (2009) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50293836
Synonyms:
CHEMBL541006 | RS-(1-(2-amino-6-oxo-7,8-dihydro-1H-purin-9(6H)-yl)-3-fluoropropan-2-yloxy)methylphosphonate
Type:
Small organic molecule
Emp. Form.:
C9H15FN5O5P
Mol. Mass.:
323.2181
SMILES:
Nc1nc2N(CC(CF)OCP(O)(O)=O)CNc2c(=O)[nH]1
Structure:
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