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Target
Thyroid hormone receptor beta
Ligand
BDBM50294980
Substrate
n/a
Meas. Tech.
ChEMBL_577226 (CHEMBL1034533)
IC50
800±n/a nM
Citation
 Hwang, JY; Arnold, LA; Zhu, F; Kosinski, A; Mangano, TJ; Setola, V; Roth, BL; Guy, RK Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem 52:3892-901 (2009) [PubMed]  Article 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM50294980
Synonyms:
1-(2-Chloro-4-(hexylthio)phenyl)-3-morpholinopropan-1-one | CHEMBL541481
Type:
Small organic molecule
Emp. Form.:
C19H28ClNO2S
Mol. Mass.:
369.949
SMILES:
CCCCCCSc1ccc(C(=O)CCN2CCOCC2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: