Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50295038
Substrate
n/a
Meas. Tech.
ChEMBL_577245 (CHEMBL1035355)
Ki
79±n/a nM
Citation
 Szabó, G; Varga, B; Páyer-Lengyel, D; Szemzo, A; Erdélyi, P; Vukics, K; Szikra, J; Hegyi, E; Vastag, M; Kiss, B; Laszy, J; Gyertyán, I; Fischer, J Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists. J Med Chem 52:4329-37 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52856.55
Organism:
Rattus norvegicus (rat)
Description:
P20272
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50295038
Synonyms:
5-(4-Cyclopropylphenyl)-1-(4-chlorophenyl)-4-methyl-N-piperidin-1-yl-1H-pyrazole-3-carboxamide | CHEMBL552155
Type:
Small organic molecule
Emp. Form.:
C25H27ClN4O
Mol. Mass.:
434.961
SMILES:
Cc1c(nn(c1-c1ccc(cc1)C1CC1)-c1ccc(Cl)cc1)C(=O)NN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: