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Target
Oxytocin receptor
Ligand
BDBM50295777
Substrate
n/a
Meas. Tech.
ChEMBL_578145 (CHEMBL1059543)
Ki
9.4±n/a nM
Citation
 Brown, A; Ellis, D; Pearce, D; Ralph, M; Sciammetta, N Aryloxypyrazines as highly selective antagonists of Oxytocin. Bioorg Med Chem Lett 19:2634-6 (2009) [PubMed]  Article 
Target
Name:
Oxytocin receptor
Synonyms:
OT-R | OXTR | OXYR_HUMAN | Oxytocin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42793.26
Organism:
Homo sapiens (Human)
Description:
Oxytocin OXTR HEK293::B2R9L7
Residue:
389
Sequence:
MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
  
Inhibitor
Name:
BDBM50295777
Synonyms:
2-(4-fluoro-2-methylphenoxy)-5-(4-(6-methoxypyridin-3-yl)-5-methyl-4H-1,2,4-triazol-3-yl)pyrazine | CHEMBL563771
Type:
Small organic molecule
Emp. Form.:
C20H17FN6O2
Mol. Mass.:
392.3864
SMILES:
COc1ccc(cn1)-n1c(C)nnc1-c1cnc(Oc2ccc(F)cc2C)cn1
Structure:
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