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Target
Replicative DNA helicase
Ligand
BDBM50295887
Substrate
n/a
Meas. Tech.
ChEMBL_578771 (CHEMBL1052344)
IC50
>100000±n/a nM
Citation
 Aiello, D; Barnes, MH; Biswas, EE; Biswas, SB; Gu, S; Williams, JD; Bowlin, TL; Moir, DT Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem 17:4466-76 (2009) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
DnaC helicase
Type:
PROTEIN
Mol. Mass.:
52545.35
Organism:
Staphylococcus aureus
Description:
ChEMBL_578771
Residue:
466
Sequence:
MDRMYEQNQMPHNNEAEQSVLGSIIIDPELINTTQEVLLPESFYRGAHQHIFRAMMHLNEDNKEIDVVTLMDQLSTEGTLNEAGGPQYLAELSTNVPTTRNVQYYTDIVSKHALKRRLIQTADSIANDGYNDELELDAILSDAERRILELSSSRESDGFKDIRDVLGQVYETAEELDQNSGQTPGIPTGYRDLDQMTAGFNRNDLIILAARPSVGKTAFALNIAQKVATHEDMYTVGIFSLEMGADQLATRMICSSGNVDSNRLRTGTMTEEDWSRFTIAVGKLSRTKIFIDDTPGIRINDLRSKCRRLKQEHGLDMIVIDYLQLIQGSGSRASDNRQQEVSEISRTLKALARELKCPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNRGGDEDDDDDGGFEPQTNDENGEIEIIIAKQRNGPTGTVKLHFMKQYNKFTDIDYAHADMM
  
Inhibitor
Name:
BDBM50295887
Synonyms:
6-ethyl-9-mercapto-6-methyl-5,6-dihydrobenzo[h][1,2,4]triazolo[3,4-b]quinazolin-7(12H)-one | CHEMBL561925
Type:
Small organic molecule
Emp. Form.:
C16H16N4OS
Mol. Mass.:
312.389
SMILES:
CCC1(C)Cc2ccccc2-c2nc3[nH][nH]c(=S)n3c(=O)c12
Structure:
Search PDB for entries with ligand similarity: