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Target
Replicative DNA helicase
Ligand
BDBM50295888
Substrate
n/a
Meas. Tech.
ChEMBL_578771 (CHEMBL1052344)
IC50
>100000±n/a nM
Citation
 Aiello, D; Barnes, MH; Biswas, EE; Biswas, SB; Gu, S; Williams, JD; Bowlin, TL; Moir, DT Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem 17:4466-76 (2009) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
DnaC helicase
Type:
PROTEIN
Mol. Mass.:
52545.35
Organism:
Staphylococcus aureus
Description:
ChEMBL_578771
Residue:
466
Sequence:
MDRMYEQNQMPHNNEAEQSVLGSIIIDPELINTTQEVLLPESFYRGAHQHIFRAMMHLNEDNKEIDVVTLMDQLSTEGTLNEAGGPQYLAELSTNVPTTRNVQYYTDIVSKHALKRRLIQTADSIANDGYNDELELDAILSDAERRILELSSSRESDGFKDIRDVLGQVYETAEELDQNSGQTPGIPTGYRDLDQMTAGFNRNDLIILAARPSVGKTAFALNIAQKVATHEDMYTVGIFSLEMGADQLATRMICSSGNVDSNRLRTGTMTEEDWSRFTIAVGKLSRTKIFIDDTPGIRINDLRSKCRRLKQEHGLDMIVIDYLQLIQGSGSRASDNRQQEVSEISRTLKALARELKCPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNRGGDEDDDDDGGFEPQTNDENGEIEIIIAKQRNGPTGTVKLHFMKQYNKFTDIDYAHADMM
  
Inhibitor
Name:
BDBM50295888
Synonyms:
2-(5-(5-mercapto-1,3,4-oxadiazol-2-yl)furan-2-yl)benzene-1,4-diol | CHEMBL561728
Type:
Small organic molecule
Emp. Form.:
C12H8N2O4S
Mol. Mass.:
276.268
SMILES:
Oc1ccc(O)c(c1)-c1ccc(o1)-c1nnc(S)o1
Structure:
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