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Target
Replicative DNA helicase
Ligand
BDBM11994
Substrate
n/a
Meas. Tech.
ChEMBL_578771 (CHEMBL1052344)
IC50
4000±n/a nM
Citation
 Aiello, D; Barnes, MH; Biswas, EE; Biswas, SB; Gu, S; Williams, JD; Bowlin, TL; Moir, DT Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem 17:4466-76 (2009) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
DnaC helicase
Type:
PROTEIN
Mol. Mass.:
52545.35
Organism:
Staphylococcus aureus
Description:
ChEMBL_578771
Residue:
466
Sequence:
MDRMYEQNQMPHNNEAEQSVLGSIIIDPELINTTQEVLLPESFYRGAHQHIFRAMMHLNEDNKEIDVVTLMDQLSTEGTLNEAGGPQYLAELSTNVPTTRNVQYYTDIVSKHALKRRLIQTADSIANDGYNDELELDAILSDAERRILELSSSRESDGFKDIRDVLGQVYETAEELDQNSGQTPGIPTGYRDLDQMTAGFNRNDLIILAARPSVGKTAFALNIAQKVATHEDMYTVGIFSLEMGADQLATRMICSSGNVDSNRLRTGTMTEEDWSRFTIAVGKLSRTKIFIDDTPGIRINDLRSKCRRLKQEHGLDMIVIDYLQLIQGSGSRASDNRQQEVSEISRTLKALARELKCPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNRGGDEDDDDDGGFEPQTNDENGEIEIIIAKQRNGPTGTVKLHFMKQYNKFTDIDYAHADMM
  
Inhibitor
Name:
BDBM11994
Synonyms:
2-{[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl}acetic acid | Interchim compound 56
Type:
Small organic molecule
Emp. Form.:
C14H15NO2S
Mol. Mass.:
261.339
SMILES:
Cc1ccc(C)n1-c1ccc(SCC(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: