Reaction Details Report a problem with these data
Target
Replicative DNA helicase
Ligand
BDBM50295890
Substrate
n/a
Meas. Tech.
ChEMBL_578771 (CHEMBL1052344)
IC50
47000±n/a nM
Citation
 Aiello, D; Barnes, MH; Biswas, EE; Biswas, SB; Gu, S; Williams, JD; Bowlin, TL; Moir, DT Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem 17:4466-76 (2009) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
DnaC helicase
Type:
PROTEIN
Mol. Mass.:
52545.35
Organism:
Staphylococcus aureus
Description:
ChEMBL_578771
Residue:
466
Sequence:
MDRMYEQNQMPHNNEAEQSVLGSIIIDPELINTTQEVLLPESFYRGAHQHIFRAMMHLNEDNKEIDVVTLMDQLSTEGTLNEAGGPQYLAELSTNVPTTRNVQYYTDIVSKHALKRRLIQTADSIANDGYNDELELDAILSDAERRILELSSSRESDGFKDIRDVLGQVYETAEELDQNSGQTPGIPTGYRDLDQMTAGFNRNDLIILAARPSVGKTAFALNIAQKVATHEDMYTVGIFSLEMGADQLATRMICSSGNVDSNRLRTGTMTEEDWSRFTIAVGKLSRTKIFIDDTPGIRINDLRSKCRRLKQEHGLDMIVIDYLQLIQGSGSRASDNRQQEVSEISRTLKALARELKCPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNRGGDEDDDDDGGFEPQTNDENGEIEIIIAKQRNGPTGTVKLHFMKQYNKFTDIDYAHADMM
  
Inhibitor
Name:
BDBM50295890
Synonyms:
CHEMBL558246 | N-(4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)-2-(5,6-diphenyl-1,2,4-triazin-3-ylthio)acetamide
Type:
Small organic molecule
Emp. Form.:
C28H24N6O4S2
Mol. Mass.:
572.658
SMILES:
Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CSc3nnc(-c4ccccc4)c(n3)-c3ccccc3)cc2)c1C
Structure:
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