Reaction Details Report a problem with these data
Target
Replicative DNA helicase
Ligand
BDBM50295894
Substrate
n/a
Meas. Tech.
ChEMBL_578771 (CHEMBL1052344)
IC50
3000±n/a nM
Citation
 Aiello, D; Barnes, MH; Biswas, EE; Biswas, SB; Gu, S; Williams, JD; Bowlin, TL; Moir, DT Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem 17:4466-76 (2009) [PubMed]  Article 
Target
Name:
Replicative DNA helicase
Synonyms:
DnaC helicase
Type:
PROTEIN
Mol. Mass.:
52545.35
Organism:
Staphylococcus aureus
Description:
ChEMBL_578771
Residue:
466
Sequence:
MDRMYEQNQMPHNNEAEQSVLGSIIIDPELINTTQEVLLPESFYRGAHQHIFRAMMHLNEDNKEIDVVTLMDQLSTEGTLNEAGGPQYLAELSTNVPTTRNVQYYTDIVSKHALKRRLIQTADSIANDGYNDELELDAILSDAERRILELSSSRESDGFKDIRDVLGQVYETAEELDQNSGQTPGIPTGYRDLDQMTAGFNRNDLIILAARPSVGKTAFALNIAQKVATHEDMYTVGIFSLEMGADQLATRMICSSGNVDSNRLRTGTMTEEDWSRFTIAVGKLSRTKIFIDDTPGIRINDLRSKCRRLKQEHGLDMIVIDYLQLIQGSGSRASDNRQQEVSEISRTLKALARELKCPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNRGGDEDDDDDGGFEPQTNDENGEIEIIIAKQRNGPTGTVKLHFMKQYNKFTDIDYAHADMM
  
Inhibitor
Name:
BDBM50295894
Synonyms:
(Z)-3-(3-chlorophenyl)-5-(4-hydroxy-3,5-dimethoxybenzylidene)-2-thioxothiazolidin-4-one | CHEMBL556099
Type:
Small organic molecule
Emp. Form.:
C18H14ClNO4S2
Mol. Mass.:
407.891
SMILES:
COc1cc(\C=C2/SC(=S)N(C2=O)c2cccc(Cl)c2)cc(OC)c1O
Structure:
Search PDB for entries with ligand similarity: