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Target
Prolyl endopeptidase FAP
Ligand
BDBM50295980
Substrate
n/a
Meas. Tech.
ChEMBL_579024 (CHEMBL1052410)
IC50
>10000±n/a nM
Citation
 Betancort, JM; Winn, DT; Liu, R; Xu, Q; Liu, J; Liao, W; Chen, SH; Carney, D; Hanway, D; Schmeits, J; Li, X; Gordon, E; Campbell, DA Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors. Bioorg Med Chem Lett 19:4437-40 (2009) [PubMed]  Article 
Target
Name:
Prolyl endopeptidase FAP
Synonyms:
170 kDa melanoma membrane-bound gelatinase | FAP | Fibroblast Activation Protein (FAP) | Fibroblast activation protein alpha | Integral membrane serine protease | SEPR_HUMAN | Seprase
Type:
Enzyme
Mol. Mass.:
87712.48
Organism:
Homo sapiens (Human)
Description:
Q12884
Residue:
760
Sequence:
MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD
  
Inhibitor
Name:
BDBM50295980
Synonyms:
(3R,6S,7aS)-6-amino-6-(4-fluorophenyl)-5-oxohexahydropyrrolo[2,1-b]thiazole-3-carbonitrile hydrochloride | CHEMBL552403
Type:
Small organic molecule
Emp. Form.:
C13H12FN3OS
Mol. Mass.:
277.317
SMILES:
N[C@@]1(C[C@@H]2SC[C@@H](C#N)N2C1=O)c1ccc(F)cc1 |r|
Structure:
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