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Target
Cyclin-dependent kinase 5
Ligand
BDBM50297029
Substrate
n/a
Meas. Tech.
ChEMBL_580987 (CHEMBL1057275)
IC50
>10000±n/a nM
Citation
 Chioua, M; Samadi, A; Soriano, E; Lozach, O; Meijer, L; Marco-Contelles, J Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors. Bioorg Med Chem Lett 19:4566-9 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50297029
Synonyms:
3-Amino-6-morpholin-4-yl-4-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile | CHEMBL552925
Type:
Small organic molecule
Emp. Form.:
C17H16N6O
Mol. Mass.:
320.3485
SMILES:
Nc1n[nH]c2nc(N3CCOCC3)c(C#N)c(-c3ccccc3)c12
Structure:
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