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Target
Collagenase 3
Ligand
BDBM50299060
Substrate
n/a
Meas. Tech.
ChEMBL_591604 (CHEMBL1042357)
IC50
190±n/a nM
Citation
 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors. J Med Chem 52:6347-61 (2009) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50299060
Synonyms:
(+/-)-2-[2-(4'-Methoxy-biphenyl-4-sulfonyl)phenyl]propionic Acid | CHEMBL584147
Type:
Small organic molecule
Emp. Form.:
C22H20O5S
Mol. Mass.:
396.456
SMILES:
COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1C(C)C(O)=O
Structure:
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