Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50299865
Substrate
n/a
Meas. Tech.
ChEMBL_589681 (CHEMBL1057686)
Ki
51±n/a nM
Citation
 Buchholz, M; Hamann, A; Aust, S; Brandt, W; Böhme, L; Hoffmann, T; Schilling, S; Demuth, HU; Heiser, U Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J Med Chem 52:7069-80 (2009) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50299865
Synonyms:
CHEMBL567406 | N-(-1-(3-(5-Methyl-1H-imidazol-1-yl)propylamino)-2-nitrovinyl)-4-chloro-benzenamine | US8772508, 7
Type:
Small organic molecule
Emp. Form.:
C15H18ClN5O2
Mol. Mass.:
335.789
SMILES:
Cc1cncn1CCCN=C(C[N+]([O-])=O)Nc1ccc(Cl)cc1 |w:9.9|
Structure:
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