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Target
Histone deacetylase 1
Ligand
BDBM50299991
Substrate
n/a
Meas. Tech.
ChEMBL_593106 (CHEMBL1042264)
IC50
>10000±n/a nM
Citation
 Ontoria, JM; Altamura, S; Di Marco, A; Ferrigno, F; Laufer, R; Muraglia, E; Palumbi, MC; Rowley, M; Scarpelli, R; Schultz-Fademrecht, C; Serafini, S; Steinkühler, C; Jones, P Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy. J Med Chem 52:6782-9 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50299991
Synonyms:
2,2,2-Trifluoro-1-(4-phenylthiophen-2-yl)ethanone | CHEMBL570806
Type:
Small organic molecule
Emp. Form.:
C12H7F3OS
Mol. Mass.:
256.244
SMILES:
FC(F)(F)C(=O)c1cc(cs1)-c1ccccc1
Structure:
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