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Target
Adenosine receptor A3
Ligand
BDBM50300679
Substrate
n/a
Meas. Tech.
ChEMBL_589466 (CHEMBL1059252)
Ki
52±n/a nM
Citation
 Lenzi, O; Colotta, V; Catarzi, D; Varano, F; Poli, D; Filacchioni, G; Varani, K; Vincenzi, F; Borea, PA; Paoletta, S; Morizzo, E; Moro, S 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition. J Med Chem 52:7640-52 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50300679
Synonyms:
5-ethyl-2-phenyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL584382
Type:
Small organic molecule
Emp. Form.:
C13H12N4O
Mol. Mass.:
240.2606
SMILES:
CCc1nc2cn(nc2c(=O)[nH]1)-c1ccccc1
Structure:
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