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Target
Sonic hedgehog protein
Ligand
BDBM50300861
Substrate
n/a
Meas. Tech.
ChEMBL_599200 (CHEMBL1049843)
IC50
119±n/a nM
Citation
 Büttner, A; Seifert, K; Cottin, T; Sarli, V; Tzagkaroulaki, L; Scholz, S; Giannis, A Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem 17:4943-54 (2009) [PubMed]  Article 
Target
Name:
Sonic hedgehog protein
Synonyms:
Hhg1 | SHH_MOUSE | Shh
Type:
Protein
Mol. Mass.:
47784.50
Organism:
Mus musculus (Mouse)
Description:
Q62226
Residue:
437
Sequence:
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
  
Inhibitor
Name:
BDBM50300861
Synonyms:
CHEMBL567378 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3-(trifluoromethyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C21H13ClF3N3O
Mol. Mass.:
415.796
SMILES:
FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1
Structure:
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