Reaction Details Report a problem with these data
Target
Equilibrative nucleoside transporter 1
Ligand
BDBM50301068
Substrate
n/a
Meas. Tech.
ChEMBL_598362 (CHEMBL1037266)
Kd
0.26±n/a nM
Citation
 Zlatopolskiy, BD; Morgenroth, A; Urusova, EA; Dinger, C; Kull, T; Pape, M; Glatting, G; Reske, SN Towards to hENT1-nucleoside transporter selective imaging agents. Synthesis and in vitro evaluation of the radiolabeled SAENTA analogues. Bioorg Med Chem Lett 19:5151-4 (2009) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM50301068
Synonyms:
5'-[(fluorescein-5-ylcarbonyl)-6-aminohexanoyl-(2-aminoethyl)]-N6-(4-nitrobenzyl)-5'-thioadenosine | CHEMBL569224
Type:
Small organic molecule
Emp. Form.:
C46H46N8O12S
Mol. Mass.:
934.969
SMILES:
O[C@@H]1[C@@H](CSCCNC(=O)CCCCCNC(=O)c2ccc3c(c2)C(=O)OC32C3=C(CC(=O)CC3)Oc3cc(O)ccc23)O[C@H]([C@@H]1O)n1cnc2c(NCc3ccc(cc3)[N+]([O-])=O)ncnc12 |r,t:30|
Structure:
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