Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50301383
Substrate
n/a
Meas. Tech.
ChEMBL_599726 (CHEMBL1048170)
IC50
>50000±n/a nM
Citation
 González, A; Quirante, J; Nieto, J; Almeida, MR; Saraiva, MJ; Planas, A; Arsequell, G; Valencia, G Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorg Med Chem Lett 19:5270-3 (2009) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50301383
Synonyms:
(E/Z)-5-bromo-3-(4-methoxyphenylimino)indolin-2-one | CHEMBL572223
Type:
Small organic molecule
Emp. Form.:
C15H11BrN2O2
Mol. Mass.:
331.164
SMILES:
COc1ccc(cc1)\N=C1/C(=O)Nc2ccc(Br)cc12
Structure:
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