Reaction Details Report a problem with these data
Target
Sodium-dependent serotonin transporter
Ligand
BDBM50301437
Substrate
n/a
Meas. Tech.
ChEMBL_600324 (CHEMBL1038400)
Ki
115.1±n/a nM
Citation
Herold, F; Izbicki, L; Chodkowski, A; Dawidowski, M; Król, M; Kleps, J; Turlo, J; Wolska, I; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Nowak, M; Pieniazek, E; Jaronczyk, M; Sylte, I; Mazurek, AP Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem 44:4702-15 (2009) [PubMed] Article
More Info.:
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
Inhibitor
Name:
BDBM50301437
Synonyms:
2-{4-[4-(2-Methyl-1H-indol-3-yl)-piperidin-1-yl]-butyl}-4-p-tolyl-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione | CHEMBL567661
Type:
Small organic molecule
Emp. Form.:
C33H40N4O2
Mol. Mass.:
524.6963
SMILES:
Cc1[nH]c2ccccc2c1C1CCN(CCCCn2c(=O)c(-c3ccc(C)cc3)c3CCCCn3c2=O)CC1