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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50301438
Substrate
n/a
Meas. Tech.
ChEMBL_600324 (CHEMBL1038400)
Ki
719±n/a nM
Citation
 Herold, F; Izbicki, L; Chodkowski, A; Dawidowski, M; Król, M; Kleps, J; Turlo, J; Wolska, I; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Nowak, M; Pieniazek, E; Jaronczyk, M; Sylte, I; Mazurek, AP Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem 44:4702-15 (2009) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50301438
Synonyms:
4-(2-Methoxy-phenyl)-2-{4-[4-(2-methyl-1H-indol-3-yl)-piperidin-1-yl]-butyl}-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione | CHEMBL569474
Type:
Small organic molecule
Emp. Form.:
C33H40N4O3
Mol. Mass.:
540.6957
SMILES:
COc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCC(CC2)c2c(C)[nH]c3ccccc23)c1=O |(22.4,-17.18,;21.07,-17.96,;19.73,-17.19,;19.73,-15.64,;18.39,-14.87,;17.06,-15.64,;17.06,-17.19,;18.39,-17.96,;18.39,-19.5,;17.05,-20.27,;15.74,-19.5,;14.41,-20.26,;14.4,-21.79,;15.73,-22.56,;17.05,-21.8,;18.38,-22.58,;18.37,-24.12,;19.72,-21.81,;21.05,-22.59,;22.38,-21.83,;23.71,-22.6,;25.05,-21.84,;26.38,-22.62,;26.36,-24.15,;27.69,-24.93,;29.03,-24.17,;29.04,-22.63,;27.71,-21.84,;30.35,-24.95,;30.51,-26.48,;29.36,-27.51,;32.01,-26.82,;32.79,-25.49,;34.29,-25.19,;34.79,-23.74,;33.77,-22.58,;32.26,-22.89,;31.77,-24.34,;19.73,-20.27,;21.06,-19.5,)|
Structure:
Search PDB for entries with ligand similarity: