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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50301441
Substrate
n/a
Meas. Tech.
ChEMBL_600324 (CHEMBL1038400)
Ki
101.3±n/a nM
Citation
 Herold, F; Izbicki, L; Chodkowski, A; Dawidowski, M; Król, M; Kleps, J; Turlo, J; Wolska, I; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Nowak, M; Pieniazek, E; Jaronczyk, M; Sylte, I; Mazurek, AP Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem 44:4702-15 (2009) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50301441
Synonyms:
4-(2-Chloro-phenyl)-2-{4-[4-(1H-indol-3-yl)-piperidin-1-yl]-butyl}-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione | CHEMBL572015
Type:
Small organic molecule
Emp. Form.:
C31H35ClN4O2
Mol. Mass.:
531.088
SMILES:
Clc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCC(CC2)c2c[nH]c3ccccc23)c1=O |(-4.37,-5.8,;-5.71,-5.03,;-5.71,-3.48,;-7.05,-2.72,;-8.38,-3.49,;-8.38,-5.04,;-7.05,-5.81,;-7.05,-7.35,;-8.39,-8.11,;-9.7,-7.35,;-11.03,-8.1,;-11.04,-9.64,;-9.71,-10.41,;-8.39,-9.65,;-7.06,-10.42,;-7.07,-11.96,;-5.72,-9.66,;-4.39,-10.44,;-3.06,-9.67,;-1.73,-10.45,;-.39,-9.69,;.94,-10.46,;.92,-12,;2.24,-12.77,;3.59,-12.02,;3.6,-10.48,;2.27,-9.69,;4.91,-12.8,;5.07,-14.33,;6.57,-14.66,;7.35,-13.34,;8.85,-13.04,;9.35,-11.58,;8.32,-10.43,;6.82,-10.73,;6.33,-12.18,;-5.71,-8.11,;-4.38,-7.35,)|
Structure:
Search PDB for entries with ligand similarity: