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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50301444
Substrate
n/a
Meas. Tech.
ChEMBL_600324 (CHEMBL1038400)
Ki
123.6±n/a nM
Citation
 Herold, F; Izbicki, L; Chodkowski, A; Dawidowski, M; Król, M; Kleps, J; Turlo, J; Wolska, I; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Nowak, M; Pieniazek, E; Jaronczyk, M; Sylte, I; Mazurek, AP Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem 44:4702-15 (2009) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50301444
Synonyms:
2-{4-[4-(1H-Indol-3-yl)-piperidin-1-yl]-butyl}-4-o-tolyl-5,6,7,8-tetrahydro-pyrido[1,2-c]pyrimidine-1,3-dione | CHEMBL570259
Type:
Small organic molecule
Emp. Form.:
C32H38N4O2
Mol. Mass.:
510.6697
SMILES:
Cc1ccccc1-c1c2CCCCn2c(=O)n(CCCCN2CCC(CC2)c2c[nH]c3ccccc23)c1=O |(21.59,-46.69,;20.25,-45.92,;20.25,-44.37,;18.9,-43.61,;17.58,-44.38,;17.58,-45.93,;18.91,-46.7,;18.91,-48.24,;17.57,-49,;16.26,-48.24,;14.93,-48.99,;14.92,-50.53,;16.25,-51.3,;17.57,-50.54,;18.9,-51.32,;18.89,-52.86,;20.24,-50.55,;21.57,-51.33,;22.9,-50.56,;24.23,-51.34,;25.57,-50.58,;26.9,-51.35,;26.88,-52.89,;28.2,-53.66,;29.55,-52.91,;29.56,-51.37,;28.23,-50.58,;30.87,-53.69,;31.03,-55.22,;32.53,-55.55,;33.31,-54.23,;34.81,-53.93,;35.31,-52.47,;34.28,-51.32,;32.78,-51.62,;32.29,-53.07,;20.24,-49,;21.58,-48.24,)|
Structure:
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