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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50301458
Substrate
n/a
Meas. Tech.
ChEMBL_600332 (CHEMBL1039276)
IC50
660±n/a nM
Citation
 Lloyd, J; Finlay, HJ; Atwal, K; Kover, A; Prol, J; Yan, L; Bhandaru, R; Vaccaro, W; Huynh, T; Huang, CS; Conder, M; Jenkins-West, T; Sun, H; Li, D; Levesque, P Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists. Bioorg Med Chem Lett 19:5469-73 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50301458
Synonyms:
6-(6-chloro-1-methyl-1H-benzo[d]imidazol-2-yl)-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine | CHEMBL567024
Type:
Small organic molecule
Emp. Form.:
C21H16Cl3N5
Mol. Mass.:
444.744
SMILES:
CC1=Nc2ccnn2C(C1c1nc2ccc(Cl)cc2n1C)c1ccc(Cl)c(Cl)c1 |t:1|
Structure:
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