Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50301559
Substrate
n/a
Meas. Tech.
ChEMBL_600518 (CHEMBL1049043)
IC50
6±n/a nM
Citation
Hanessian, S; Therrien, E; Zhang, J; Otterlo, W; Xue, Y; Gustafsson, D; Nilsson, I; Fjellström, O From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett 19:5429-32 (2009) [PubMed] Article
More Info.:
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Inhibitor
Name:
BDBM50301559
Synonyms:
CHEMBL569249 | N-(4-carbamimidoylbenzyl)-2-(1-(2,5-dimethylphenylsulfonamido)-4-methyl-2-oxo-1,2,5,6-tetrahydropyridin-3-yl)acetamide
Type:
Small organic molecule
Emp. Form.:
C24H29N5O4S
Mol. Mass.:
483.583
SMILES:
CC1=C(CC(=O)NCc2ccc(cc2)C(N)=N)C(=O)N(CC1)NS(=O)(=O)c1cc(C)ccc1C |c:1|