Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50301650
Substrate
n/a
Meas. Tech.
ChEMBL_600730 (CHEMBL1037442)
IC50
2.3±n/a nM
Citation
 Takahashi, H; Haga, Y; Shibata, T; Nonoshita, K; Sakamoto, T; Moriya, M; Ohe, T; Chiba, M; Mitobe, Y; Kitazawa, H; Iwaasa, H; Ishihara, A; Ishii, Y; Kanatani, A; Fukami, T Identification of positron emission tomography ligands for NPY Y5 receptors in the brain. Bioorg Med Chem Lett 19:5436-9 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50301650
Synonyms:
CHEMBL584732 | trans-N-(5-(3-(fluoromethyl)phenyl)pyrimidin-2-yl)-7'-oxo-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H21FN4O3
Mol. Mass.:
432.4469
SMILES:
FCc1cccc(c1)-c1cnc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ncccc32)nc1 |r,wU:18.22,wD:15.15,(31.96,-37.33,;30.62,-36.56,;29.29,-37.34,;29.3,-38.89,;27.96,-39.66,;26.63,-38.89,;26.63,-37.35,;27.95,-36.58,;25.3,-36.58,;23.96,-37.35,;22.63,-36.58,;22.64,-35.04,;21.3,-34.27,;19.97,-35.04,;18.64,-34.27,;19.97,-36.58,;18.64,-37.36,;18.64,-38.9,;19.97,-39.66,;21.3,-38.9,;21.3,-37.36,;20.89,-40.91,;19.98,-42.17,;20.47,-43.63,;18.51,-41.7,;17.17,-42.47,;15.83,-41.7,;15.83,-40.16,;17.16,-39.39,;18.5,-40.15,;23.96,-34.27,;25.29,-35.03,)|
Structure:
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