Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50301653
Substrate
n/a
Meas. Tech.
ChEMBL_600730 (CHEMBL1037442)
IC50
2.2±n/a nM
Citation
 Takahashi, H; Haga, Y; Shibata, T; Nonoshita, K; Sakamoto, T; Moriya, M; Ohe, T; Chiba, M; Mitobe, Y; Kitazawa, H; Iwaasa, H; Ishihara, A; Ishii, Y; Kanatani, A; Fukami, T Identification of positron emission tomography ligands for NPY Y5 receptors in the brain. Bioorg Med Chem Lett 19:5436-9 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50301653
Synonyms:
CHEMBL583007 | trans-N-(5-(4-fluorophenyl)pyrimidin-2-yl)-3'-oxo-3'H-spiro[cyclohexane-1,1'-furo[3,4-c]pyridine]-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H19FN4O3
Mol. Mass.:
418.4204
SMILES:
Fc1ccc(cc1)-c1cnc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2cnccc32)nc1 |r,wU:17.21,wD:14.14,(33,-12.26,;31.67,-11.49,;30.33,-12.27,;29,-11.5,;29,-9.96,;30.33,-9.18,;31.66,-9.95,;27.67,-9.19,;26.33,-9.96,;25,-9.19,;25.01,-7.65,;23.68,-6.88,;22.34,-7.65,;21.01,-6.88,;22.34,-9.19,;21.01,-9.97,;21.01,-11.51,;22.34,-12.27,;23.67,-11.51,;23.67,-9.97,;23.26,-13.52,;22.36,-14.78,;22.84,-16.24,;20.88,-14.31,;19.54,-15.08,;18.2,-14.31,;18.21,-12.76,;19.53,-11.99,;20.87,-12.76,;26.33,-6.88,;27.66,-7.64,)|
Structure:
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