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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50301782
Substrate
n/a
Meas. Tech.
ChEMBL_598082 (CHEMBL1049772)
EC50
96±n/a nM
Citation
 Andrews, MD; Green, MP; Allerton, CM; Batchelor, DV; Blagg, J; Brown, AD; Gordon, DW; McMurray, G; Millns, DJ; Nichols, CL; Watson, L Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists. Bioorg Med Chem Lett 19:5346-50 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50301782
Synonyms:
2-(3-chlorophenethyl)-3-methyl-6-(piperazin-1-yl)pyrimidin-4(3H)-one | CHEMBL577831
Type:
Small organic molecule
Emp. Form.:
C17H21ClN4O
Mol. Mass.:
332.828
SMILES:
Cn1c(CCc2cccc(Cl)c2)nc(cc1=O)N1CCNCC1
Structure:
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