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Target
Dickkopf-related protein 1
Ligand
BDBM50303035
Substrate
n/a
Meas. Tech.
ChEMBL_597250 (CHEMBL1043427)
EC50
7800±n/a nM
Citation
 Pelletier, JC; Lundquist, JT; Gilbert, AM; Alon, N; Bex, FJ; Bhat, BM; Bursavich, MG; Coleburn, VE; Felix, LA; Green, DM; Green, P; Hauze, DB; Kharode, YP; Lam, HS; Lockhead, SR; Magolda, RL; Matteo, JJ; Mehlmann, JF; Milligan, C; Murrills, RJ; Pirrello, J; Selim, S; Sharp, MC; Unwalla, RJ; Vera, MD; Wrobel, JE; Yaworsky, P; Bodine, PV (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem 52:6962-5 (2009) [PubMed]  Article 
Target
Name:
Dickkopf-related protein 1
Synonyms:
DKK1 | DKK1_HUMAN
Type:
PROTEIN
Mol. Mass.:
28687.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_597250
Residue:
266
Sequence:
MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
  
Inhibitor
Name:
BDBM50303035
Synonyms:
4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)benzenesulfonamide | CHEMBL569998
Type:
Small organic molecule
Emp. Form.:
C15H14N4O2S2
Mol. Mass.:
346.427
SMILES:
Cc1ccc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1
Structure:
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