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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50303035
Substrate
n/a
Meas. Tech.
ChEMBL_597251 (CHEMBL1043428)
IC50
200±n/a nM
Citation
 Pelletier, JC; Lundquist, JT; Gilbert, AM; Alon, N; Bex, FJ; Bhat, BM; Bursavich, MG; Coleburn, VE; Felix, LA; Green, DM; Green, P; Hauze, DB; Kharode, YP; Lam, HS; Lockhead, SR; Magolda, RL; Matteo, JJ; Mehlmann, JF; Milligan, C; Murrills, RJ; Pirrello, J; Selim, S; Sharp, MC; Unwalla, RJ; Vera, MD; Wrobel, JE; Yaworsky, P; Bodine, PV (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem 52:6962-5 (2009) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50303035
Synonyms:
4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)benzenesulfonamide | CHEMBL569998
Type:
Small organic molecule
Emp. Form.:
C15H14N4O2S2
Mol. Mass.:
346.427
SMILES:
Cc1ccc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1
Structure:
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