Reaction Details Report a problem with these data
Target
Dickkopf-related protein 1
Ligand
BDBM50303040
Substrate
n/a
Meas. Tech.
ChEMBL_597250 (CHEMBL1043427)
EC50
9800±n/a nM
Citation
 Pelletier, JC; Lundquist, JT; Gilbert, AM; Alon, N; Bex, FJ; Bhat, BM; Bursavich, MG; Coleburn, VE; Felix, LA; Green, DM; Green, P; Hauze, DB; Kharode, YP; Lam, HS; Lockhead, SR; Magolda, RL; Matteo, JJ; Mehlmann, JF; Milligan, C; Murrills, RJ; Pirrello, J; Selim, S; Sharp, MC; Unwalla, RJ; Vera, MD; Wrobel, JE; Yaworsky, P; Bodine, PV (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem 52:6962-5 (2009) [PubMed]  Article 
Target
Name:
Dickkopf-related protein 1
Synonyms:
DKK1 | DKK1_HUMAN
Type:
PROTEIN
Mol. Mass.:
28687.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_597250
Residue:
266
Sequence:
MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
  
Inhibitor
Name:
BDBM50303040
Synonyms:
4-(methyl(4-(5-methylthiophen-2-yl)pyrimidin-2-yl)amino)benzenesulfonamide | CHEMBL571525
Type:
Small organic molecule
Emp. Form.:
C16H16N4O2S2
Mol. Mass.:
360.454
SMILES:
CN(c1ccc(cc1)S(N)(=O)=O)c1nccc(n1)-c1ccc(C)s1
Structure:
Search PDB for entries with ligand similarity: