Reaction Details Report a problem with these data
Target
Polyphenol oxidase 2
Ligand
BDBM50304067
Substrate
n/a
Meas. Tech.
ChEMBL_601541 (CHEMBL1044238)
IC50
>100000±n/a nM
Citation
 Matsuda, H; Nakashima, S; Oda, Y; Nakamura, S; Yoshikawa, M Melanogenesis inhibitors from the rhizomes of Alpinia officinarum in B16 melanoma cells. Bioorg Med Chem 17:6048-53 (2009) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50304067
Synonyms:
(R)-5-hydroxy-1,7-diphenylheptan-3-one | CHEMBL594066
Type:
Small organic molecule
Emp. Form.:
C19H22O2
Mol. Mass.:
282.3768
SMILES:
O[C@H](CCc1ccccc1)CC(=O)CCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: