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Target
Mu-type opioid receptor
Ligand
BDBM50304074
Substrate
n/a
Meas. Tech.
ChEMBL_601578 (CHEMBL1047758)
IC50
1.15±n/a nM
Citation
 Deb, I; Paira, P; Hazra, A; Banerjee, S; Dutta, PK; Mondal, NB; Das, S Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence. Bioorg Med Chem 17:5782-90 (2009) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | Opiate non-selective | Opioid receptor B | OPRM_RAT | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rat
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50304074
Synonyms:
2-(2-methylquinolin-4-ylamino)-N-phenylacetamide | CHEMBL594511
Type:
Small organic molecule
Emp. Form.:
C18 H17 N3 O
Mol. Mass.:
291.34708
SMILES:
Cc1cc(NCC(=O)Nc2ccccc2)c2ccccc2n1
Structure:
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